Body Size, Diet Quality, and Epigenetic Aging: Cross-Sectional and Longitudinal Analyses

DL Li; AM Hodge; L Cribb; MC Southey; GG Giles; RL Milne; PA Dugué

Journal article

Body Size, Diet Quality, and Epigenetic Aging: Cross-Sectional and Longitudinal Analyses

DL Li, AM Hodge, L Cribb, MC Southey, GG Giles, RL Milne, PA Dugué

The journals of gerontology. Series A, Biological sciences and medical sciences | Oxford University Press | Published : 2024

DOI: 10.1093/gerona/glae026

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Abstract

Epigenetic age is an emerging marker of health that is highly predictive of disease and mortality risk. There is a lack of evidence on whether lifestyle changes are associated with changes in epigenetic aging. We used data from 1 041 participants in the Melbourne Collaborative Cohort Study with blood DNA methylation measures at baseline (1990–1994, mean age: 57.4 years) and follow-up (2003–2007, mean age: 68.8 years). The Alternative Healthy Eating Index-2010 (AHEI-2010), the Mediterranean Dietary Score, and the Dietary Inflammatory Index were used as measures of diet quality, and weight, waist circumference, and waist-to-hip ratio as measures of body size. Five age-adjusted epigenetic aging..

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University of Melbourne Researchers

Allison Hodge Author

Melissa Southey Author

Graham Giles Author

Roger Milne Author

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Grants

Awarded by Cancer Council Victoria

Funding Acknowledgements

Melbourne Collaborative Cohort Study (MCCS) cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by Australian National Health and Medical Research Council (NHMRC) grants 209057, 396414, and 1074383 and by infrastructure provided by Cancer Council Victoria. The nested case-control methylation studies were supported by the NHMRC Grants 1011618, 1026892, 1027505, 1050198, 1043616, and 1074383. The longitudinal methylation study was supported by the NHMRC grants 1088405 and 1106016.